MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism
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چکیده
منابع مشابه
MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism
Metabolism is remodeled when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), but the majority of iPSCs are not fully reprogrammed. In a shift essential for reprogramming, iPSCs use less mitochondrial respiration but increased anaerobic glycolysis for bioenergetics. We found that microRNA 31 (miR-31) suppressed succinate dehydrogenase complex subunit A (SDHA) expressi...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2016
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2016.05.012